Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.
نویسندگان
چکیده
OBJECTIVE To investigate the role of thrombospondin 1 (TSP-1) in RA. METHODS Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined. RESULTS Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1. CONCLUSION TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.
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عنوان ژورنال:
- The Journal of rheumatology
دوره 42 6 شماره
صفحات -
تاریخ انتشار 2015